hcv polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T27586	IDX184	IDX-184,IDX 184	HCV Protease
	IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with ant...		HCV Protease
T17029	Tegobuvir	GS-9190,GS 333126	HCV Protease
	Tegobuvir (GS 333126) is a specific and covalent HCV NS5B polymerase inhibitor.		HCV Protease
T26815	BILB-1941	BILB 1941ZW,BILB1941ZW,BILB-1941ZW	HCV Protease
	BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection.		HCV Protease
TQ0122L	VCH-916 free acid(1200133-34-1 free base)		HCV Protease
	VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.		HCV Protease
TNU0442	2’-beta-C-Methyl inosine	2'-C-Methylinosine	Antiviral , DNA/RNA Synthesis
	2'-beta-C-Methyl inosine (2'-C-Methylinosine) is an HCV RNA polymerase inhibitor with antiviral activity that has been investigated for the treatment of Hepatitis C Virus infections. ccc_R08 is an inhibitor of HCV RNA po...		Antiviral , DNA/RNA Synthesis
TQ0090	Nesbuvir	HCV-796	HCV Protease
	Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.		HCV Protease
T7607	PSI-6130	R 1656	HCV Protease
	PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.		HCV Protease
T2117	PSI-6206	2'-deoxy-2'-fluoro-2'-C-methyluridine,RO 2433,GS-331007	HCV Protease
	PSI-6206 (RO 2433) (RO2433) is a selective HCV RNA polymerase inhibitor.		HCV Protease
T16710	Mericitabine	R-7128,RG 7128,PSI 6130 diisobutyrate	HCV Protease
	Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication.		HCV Protease
T15282	Filibuvir	PF-00868554	HCV Protease , DNA/RNA Synthesis
	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.		HCV Protease , DNA/RNA Synthesis
T6676	Sofosbuvir	GS 7977,PSI-7977	HCV Protease
	Sofosbuvir (GS 7977) is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment of chronic hepatitis C.		HCV Protease
T21537L	TMC647055 Choline Hydroxide Salt	TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease
	TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with mi...		HCV Protease
T28762	Setrobuvir	RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease , SARS-CoV , DNA/RNA Synthesis
	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding aff...		HCV Protease , SARS-CoV , DNA/RNA Synthesis
T7215	NM107	NM-107,2'-C-Methylcytidine	HCV Protease
	NM107 (2'-C-Methylcytidine) is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, NM 107 in the wild-type replicon cells with the EC50 of 1...		HCV Protease
T27530	HCV-086	HCV086
	HCV-086, a RNA-directed RNA polymerase (NS5B) inhibitor, is used for the treatment of HCV infection.
T29069	Uprifosbuvir	MK3682,IDX21437,IDX 21437,MK 3682,IDX-21437,MK-3682
	Uprifosbuvir is an inhibitor of uridine nucleotide analog HCV NS5B polymerase.
T27587	IDX-375
	IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.